General anesthesia decouples cortical pyramidal neurons Mototaka & Larkum, 2020
The mystery of general anesthesia is that it specifically suppresses consciousness by disrupting feedback signaling in the brain, even when feedforward signaling and basic neuronal function are left relatively unchanged. The mechanism for such selectiveness is unknown. Here we show that three different anesthetics have the same disruptive influence on signaling along apical dendrites in cortical layer 5 pyramidal neurons in mice. We found that optogenetic depolarization of the distal apical dendrites caused robust spiking at the cell body under awake conditions that was blocked by anesthesia. Moreover, we found that blocking metabotropic glutamate and cholinergic receptors had the same effect on apical dendrite decoupling as anesthesia or inactivation of the higher-order thalamus. If feedback signaling occurs predominantly through apical dendrites, the cellular mechanism we found would explain not only how anesthesia selectively blocks this signaling but also why conscious perception depends on both cortico-cortical and thalamo-cortical connectivity.
|Other Tags||general anesthesia anesthesia brain apical dendrites cortical layer 5 pyramidal neurons mice cell body apical dendrite thalamus cortical connectivity larkumlab_project highlighted_results_sfb1315 Visual-abstract|
- Created: 17 Jun 2020 05:06:18 | Last updated: 17 Jun 2020 05:06:17